The Essential Guide to Neopost / Quadient Ink Cartridges

Every office has that one piece of equipment you can’t afford to let sit idle. For businesses that handle regular postage, it’s the mailing system. Whether you’re running a Neopost IS series machine or one of the larger Quadient mailroom workhorses, having the right ink cartridge ready makes the difference between a smooth day and a frustrating pile-up of unsent envelopes.

The problem? Not all cartridges are the same. Some are built for light daily use, while others are high-capacity tanks designed to keep large operations moving. Choosing the wrong one often leads to wasted money, faded postage, or downtime that slows the whole team.

Let’s break down the most important Neopost / Quadient ink cartridges, where each one fits best, and how they can save you time and money.

Standard Ink Cartridges: Everyday Reliability

For smaller offices or teams with steady but moderate mailing needs, standard cartridges do the job perfectly.

The ISINK2 – 2 Series Standard Capacity Ink Cartridge is built for the compact 2 Series systems. It’s affordable, reliable, and ideal when your volume is light to medium.
The ISINK34 – Ink Cartridge for IS3/4 Series takes things up a notch. Designed for the IS3 and IS4 machines, it gives you crisp impressions that meet postal standards without breaking the budget.

Think of these as your daily drivers—solid performance without the extra cost of high-capacity models.

High-Capacity Cartridges: Fewer Replacements, More Output

If you’re in a busier mailroom, the last thing you want is to keep swapping out cartridges. That’s where high-capacity options step in.

The ISINK4HC – IS 4 Series High-Capacity Ink Cartridge is perfect for businesses using the IS4 system but with heavier daily throughput. It lasts longer and keeps impressions sharp.
The ININK67HC – Neopost High-Capacity Ink Cartridge is another popular choice for high-volume mailers. By extending the replacement cycle, it saves staff time and keeps operations smooth.
High-capacity cartridges aren’t just about convenience—they lower your cost per impression, making them more economical long-term.

Specialized Cartridges for Heavy-Duty Systems

Larger machines have larger demands.

The IS56INK – IS5000/IS6000 Compatible Ink Tank is built for enterprise-level setups. If you’re running thousands of envelopes per day, this is the workhorse cartridge your system depends on.
For compact but highly efficient machines, the 3300028D – Neopost Ink Cartridge IJ25 (2600 Stamps) provides exactly what it promises: clear postage for up to 2,600 impressions. It’s cost-effective and perfectly matched for the IJ25 model.
The ININK67 – Neopost Ink Cartridge works as a general option across multiple systems. It’s flexible, reliable, and often the go-to for offices that need a straightforward cartridge without overcomplicating things.

How to Pick the Right Cartridge for Your Office

When choosing your ink, keep three things in mind:

Mailing Volume – Fewer than a couple hundred pieces a week? Stick with ISINK2 or ISINK34. Sending thousands? You’ll want ISINK4HC, ININK67HC, or IS56INK.
Machine Model – Each cartridge is designed for specific machines. Always double-check compatibility before ordering.
Budget & Efficiency – High-capacity cartridges cost more upfront but reduce downtime and lower costs in the long run.

Maintenance Tips to Get the Most Out of Your Cartridges

Store sealed cartridges in a cool, dry place.
Run test prints if your volume is low, so ink doesn’t dry inside the head.
Replace cartridges before they’re completely empty to avoid faded impressions.
Stick to compatible cartridges like ISINK34 or ININK67 to protect your machine from damage.

Final Thoughts

Your Neopost / Quadient mailing system is built to make life easier—but only if you give it the right supplies. From the everyday reliability of the ISINK2 Standard Cartridge to the heavy-duty power of the IS56INK Tank, the right ink ensures your mailroom stays efficient, compliant, and professional.